Stable monotherapy with clozapine or olanzapine increases the incidence of diabetes mellitus in people with schizophrenia.

Risk factors: Participants diagnosed with diabetes mellitus or hospitalised with diabetic ketoacidosis were identified from the Department of Veterans Affairs and were predominantly older and male. Time to diagnosis and hospitalisation was modelled using the Cox proportional hazards models. Attributable risks of each outcome associated with different antipsychotics were calculated. The five antipsychotics groups analysed were: clozapine, olanzapine, quetipane, risperidone, and control (all conventional antipsychotics).